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KMID : 0869620000170020265
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Journal of Korean Society of Hospital Pharmacists
2000 Volume.17 No. 2 p.265 ~ p.271
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Therapeutic Drug Monitoring of Vancomycin
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Ahn Hye-Lim
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Abstract
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The results of therapeutic drug monitoring (TDM) service were evaluated. Total 78 cases of peak and trough concentration of vancomycin were obtained on steady state. The 54 cases of all were obtained prior to TDM service. Statistically significant differences were observed between population vancomycin clearance by CAPCIL^(®) computer program and Bayesian clearance by Bayesian method. Only 48.1% of the 54 cases given empirical dose of vancomycin were within therapeutic range. After TDM service, 23% (18/78 cases) were recommended dose reduction and 66.7% (12/18 cases) were accepted. Drug concentration were obtained from 15 cases who received modified dose through TDM service and 13 cases of them were within expected range. The total drug saving were 257 vials in 9 patients who were administered reduction dose (9/54 cases) and the calculated mean cost saving per case was 321,907 won (range : 78,911~473,466).
In conclusion, TDM service for vancomycin is necessary to obtain optimal therapeutic drug level and for the cost saving. Furthermore the vancomycin dosing nomogram in Korean population should be developed.
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KEYWORD
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